ANCA-pathophysiology revisited
نویسندگان
چکیده
منابع مشابه
Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?
The strong relation between antineutrophil cytoplasmic autoantibodies (ANCA) and primary vasculitic syndromes suggests a pathophysiological role for ANCA. Experimental evidence for the pathogenic potential of ANCA has been derived from in vitro studies that demonstrate that ANCA can activate tumour necrosis factor alpha primed neutrophils, monocytes and/or endothelial cells. The binding of ANCA...
متن کاملPathophysiology of ANCA-Associated Small Vessel Vasculitis
Antineutrophil cytoplasmic autoantibodies (ANCAs) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are strongly associated with the ANCA-associated vasculitides--Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome. Clinical observations, including the efficacy of B-cell depletion via rituximab treatment, support--but do not prove--a pathogenic role fo...
متن کاملPathophysiology of ANCA-associated vasculitis: are ANCA really pathogenic? A note of caution.
1. MANJUNATH G, SARNAK MJ, LEVEY AS: Prediction equations to estimate glomerular filtration rate: An update. Curr Opin Nephrol Hypertens 10:785–792, 2001 2. NATIONAL KIDNEY FOUNDATION: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 39(Suppl 1):S1–266, 2002 3. KEITH DS, NICHOLS GA, GULLION CM, et al: Longitudinal fo...
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Substantial progress has been made over the last two decades in our understanding of the immunopathogenesis of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides. Compelling evidence from in vitro studies and experimental models in conjunction with clinical trials has confirmed that ANCA directly contribute to the evolution and progression of the disease process. Continuous de...
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In 1856, Rudolf Virchow published “Cellular pathology” based on macroscopic and microscopic observation of diseases, and described a triad of factors on thrombosis. The three components were vascular change, blood flow alteration, and abnormalities of blood constituents. Although Virchow originally referred to venous thrombosis, the theory can also be applied to arterial thrombosis, and it is c...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.1995.tb03594.x